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In this first lecture video of three in the Frontiers of Science unit on biodiversity, Columbia University professor Don Melnick identifies ecological problems on a global scale, such as degradation of land and aquatic ecosystems, accumulation of greenhouse gases, decline of species and emerging infectious diseases. The basic science behind investigating the problems facing humans in the twenty-first century is discussed at 3 different scales: gene, species and ecosystem. A lecture transcript and companion presentation are also available on FoSO.