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In this final lecture of three in the Frontiers of Science unit on climate change, Columbia University Professor Peter deMenocal discusses the scientific exploration of the nature of the Cretaceous-Tertiary extinction event. He explores the alternative hypotheses for the event that have been put forward over the years and provides examples of current supporting evidence. The lecture also emphasizes how dogma can be the enemy of scientific progress when it causes scientists to see what they expect to see instead of what the data actually shows. A lecture transcript and companion PowerPoint presentation are also available on FoSO.